[Comparison of androgenic alopecia distribution among type 2 diabetes and healthy women in Isfahan city: a brief report]

Insulin resistant is important risk factors of diabetes and leads to development of chronic diseases such as diabetes and cardiovascular disease. Recent studies showed association between androgenic alopecia and insulin resistant. However, findings are controversial. Alopecia in women is a common heritable hair loss in central part of head. Aim of this study was investigation of androgenic alopecia distribution in type II diabetes and healthy women and hypothesis testing of relationship between diabetes and androgenic alopecia. This is a case-control study. Case and control groups were selected from type H diabetes and healthy women respectively that were refered to clinics of Alzahra, Noor and Amin Hospitals in Isfahan City, Iran in 2011. Participants were selected based on random sampling. Sample size was estimated 141 subjects in each group. Participants were visited by doctor and severity of androgenic alopecia was determined based on Ludwish criteria. Data were analyzed with SPSS software and chi[2] test. P<0.05 was considered as significant. Mean age and body mass index were 58.96+12.8 year and 25.6+4.15 kg/m- respectively in whole population. Findings not show any significant association between type II diabetes and androgenic alopecia [P<0.05]. Comparison of distribution of alopecia severity according to Ludwish criteria separately showed similar result. In addition to, there was not any significant relationship between diabetes and alopecia after adjusting with body mass index as confounding factor [P<0.05]. In the present study, there was not any significant relationship between type II diabetes and androgenic alopecia among diabetes and healthy women. However, more researches need to investigate this relationship in both gender and assess insulin resistant indices as homeostasis model assessment-estimated insulin resistance and androgenic alopecia

[Efficacy of integration methods in the control of cutaneous Leishmaniasis in Imamzadeh Agha Ali Abbas in Natanz in Isfahan in 1996-98]

Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, the integration of methods is considerable

Objective: To evaluate the efficacy of integration method in the control of cutaneous leishmaniasis

Patients and Methods: This study was an interventional study, which after knowing the ecosystem around the Imamzadeh Agha Ali Abbas in Natanz in Isfahan, perform the plat covering within a radius of 100m, entrances correction, pool and garbage storage removal and sweepings for the rodents within a radius of 2kms around the Imamzadeh and poisoning the vectors have been done

Results: The incidence of disease was 3.7% in 1996 [Before intervention], which was decreased to 1/17 in 1996 and to 1/12 a year later

Conclusion: Integration method consisting of environment improvement, rodents removal and poisoning as well as training high risk people is recommended to control cutaneous leishmaniasis

Patch test results in patients with clinical diagnoses of contact and/or atopic dermatitis in Isfahan

Patch testing is an important diagnostic tool to confirm allergic contact dermatitis. Determination of the validity and usefulness of a standard patch test allergen series with consideration of age, sex and race difference can reduce diagnostic errors in patients with allergic contact dermatitis. This study was done to determine the frequency of contact sensitization to 28 common allergens in patients with clinical diagnoses of contact and/or atopic dermatitis. Materials and In a cross sectional study during 6 months, 250 patients with contact and/or atopic dermatitis were patch tested with DKG standard patch test series and evaluated after 24, 48 and 72 hours after application of patch test. Data were analyzed using SPSS. 11 software by X[2], Fisher's exact and t tests. Positive patch test results were seen in 32% of all evaluated patients. 45.8% of patients with age above 40 years and 28.0% of patient with age below 40 years had a positive patch test. Potassium dichromate and nikel sulfate were the most common allergens in our study. In this study only 13 of 18 [46.4%] tested allergens showed positive reaction. Low positive rate of standard DKG series in this study shows that allergen series of standard patch test should be revised based on reginal conditions, allergens and social habits

comparative study on the efficacy of combination therapy with omeprazole and low dose systemic meglumine antimoniate [Glucantime] and the full dose systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis

Pentavalent antimony compounds are the first line of treatment of cutaneous leishmaniasis. However, because of their potential toxic effects attempts to find more effective and safer drugs still is in function. The objective of this study was to compare the efficacy of oral omeprazole and low dose systemic meglumine antimoniate [MA] and full dose systemic MA in the treatment of cutaneous leishmaniasis. A double blind clinical trial was performed on 150 patients with cutaneous leishmaniasis. The patients were randomly divided to three groups: l]intramuscular injections of MA [60 mg/kg/day] and oral placebo for three weeks; 2] intramuscular injections of MA [30 mg/kg/day] and oral omeprazole [40 mg/day] for three weeks; 3] intramuscular injections of MA [30 mg/kg/day] and oral placebo for three weeks. All patients were visited every two weeks from the beginning of the trial up to 6 weeks and then at 8 and 12 weeks. The effectiveness of the treatment was classified in three levels as complete response, partial response and failure. Data were analyzed by SPSS software version 10 by using X [2], Mann-Whitney, Kaplan-Mayer and ANOVA t tests. Three months after the treatment, complete response and partial response in group one [43 patients] were 93% and 0%, respectively, which were significantly higher than other two groups [P<0.05]. Complete response and partial response were 88.9% and 2.8% in group two [36 patients], and 80% and 2.2% in group three [45 patients], respectively. Efficacy of the treatment in group two was significantly higher than group three [P<0.05]. Although oral omeprazole and low dose of systemic MA showed less efficacy in comparison to standard dose of systemic MA in treatment of cutaneous leishmaniasis, it can be considered as an alternative therapy in high risk patients [such as patients with heart, kidney and/or liver disease] under close supervision of specialized physician

Evaluation of efficacy of diode laser treatment on unwanted hair

Unwanted hair has been one of the problems that many researches have dealt with. There are several ways for removal of unwanted hairs including laser. Laser hair removal is a new method in this field and the main objective of this study was to assess its effectiveness in Iranian patients.This study was done on 58 patients attending Isfahan's Shahid Beheshti Laser Center for laser hair removal. In the first session, diode laser [42-61 J/cm [2], 810 nm wave length, 200 msec pulse duration, 5 mm spot size] was used and if there was not any severe skin reaction, it was repeated up to four times at 1-1.5 month intervals. The main outcome measure was the number of hairs per cm [2] counted from digital photographs taken before the treatment and one month after the last treatment. All patients were followed up to 4 months after their last laser session. Fifty-eight patients with mean age of 30 years, Fitzpatrick skin types of II, III and IV and predominant black unwanted hairs were treated with a 810 nm diode laser. The mean hair reduction was 64% and the most reduction was seen in patients with skin type IV [70.4%]. The most common side effect was transient post laser erythema [34.5%]. There was a weak and negative but significant relation between the clearance rate and energy fluence [r = 0.29, P<0.05]. However, the relation between the age of the patients and clearance rate was positive [r = 0.42, P<0.05]. 810 nm diode laser is an effective and safe hair removal method in Iranian patients. The effect of energy fluence and age of the patients on the final hair reduction in the patients merits further attention in future studies